Duplicating Lil Clot trinkets will cause them to stack, allowing Isaac to control multiple Lil Clots at once. in The Chest as Apollyon, Upon entering a room with enemies, spawns a Black Locust that deals quadruple Isaac's damage, applied as two hits of double damage, UNLOCK: Unlock this trinket by defeating The Lamb as Apollyon, At the start of each new hostile room you spawn 2-5 white attack flies, which will target a nearby enemy and deal double your tear damage to it, UNLOCK: Unlock this trinket by defeating Boss Rush as Apollyon, When killing an enemy, you have a very small chance to gain the ability to fly for the rest of the room, UNLOCK: Unlock this trinket by defeating Greedier Mode with Azazel, Stem Cell heals Isaac's red heart containers to 50% each floor, If Isaac already has 50% health or more, it heals half of a heart instead, UNLOCK: Unlock this trinket by defeating Greedier Mode with Samson, Fully recharges your active item at the start of each boss fight, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Zaratus, Gives you the Holy Mantle shield effect at the start of every new floor, which protects you from the next hit of damage you take, Does not recharge until the start of the next floor, Stacks with the effects from Holy Mantle and Blanket, but it does not stack with Holy Card, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Ep and Mills, Using your active item while holding this trinket will drop it back on a pedestal on the ground, Also after taking damage, you have a very small chance to drop one of your passive items, One-time use active items will be consumed and not dropped, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by MarkusLeben and iguesti, *, yellow, golden, box, block, square, cube, Holding this trinket will cause the Angel mini bosses to drop normal items instead of Key Pieces, Added as part of the Afterbirth+ Booster Pack #2, designed by Edmund McMillen, While held, the last door Isaac went through stays open, allowing him to leave the room even if enemies are in it, This trinket works on boss rooms (except Ultra Greed) and devil rooms containing Krampus, allowing you to exit out mid-fight, UNLOCK: Unlock this trinket by blowing up doors and secret room walls 50 times, *, door, stop, wedge, cheese, wood, brown, hodor, game of thrones, Wylis, After being picked up, a yellow laser chain now flows through Isaac's familiars, Added as part of the Afterbirth+ Booster Pack #4 and based on the Steam Workshop mod created by Strawrat and Aczom, While held, spawns +1 friendly blue fly every time you pick up a coin, Added as part of the Afterbirth+ Booster Pack #5. . Unlocked from Challenge #24 - PAY TO PLAY, Power Pill - Gives you invulnerability and the ability to damage enemies for a short while (similar to The Gamekid effect), Re-Lax - Causes Isaac to spawn poops behind him while he walks for a few seconds. Curses Curses The ram horns gained from picking up Brimstone were added as a. Maggy - +1 HP up. Why? Based on the Steam Workshop mod (originally called Lightshot) created by Wyvern and TRPG, Pressing the CTRL key (R2 on PS4, RT on XB1, ZR on Switch) allows you to switch active items, Some items that give temporary effects like The Nail might deactivate if switched to the other slot, Added as part of the Afterbirth+ Booster Pack #4, UNLOCK: Unlock this item by entering every Shop from the first floor up to Mom's Foot (Depths 2) in one run, Grants you a shield when entering the Boss Room, which prevents damage from 1 hit, then disappears. If an enemy is killed while it is golden, it will drop between 1-4 coins, Contact damage is also dealt to enemies equal to the amount of coins Isaac is currently holding, Has a synergy with The Poop item, which gives it a high chance to spawn golden poops, * item room, treasure room, item room pool, gold, ingot, bar, orange, All future pennies, keys, bombs and hearts have a chance to drop in pairs, Does not work for other pickups, such as soul hearts, nickels, dimes, cards, pills etc, REPENTANCE - No longer guarantees all pickups to be doubled (is now chance-based), and doesn't change existing pickups that already dropped, * Humbling bundle shop room pool, shop item pool, paper, purple, brown, When you take damage, there is a 50% chance to drop a random heart, key, bomb or coin, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool, bag, satchel, backpack, purse, satchel, brown, When your spacebar item is not fully charged, you can press spacebar to recharge it at the cost half of a heart per charge, Will not kill you if used - it stops a half a heart left, Red hearts are taken before other kinds, i.e. The damage bonus is unaffected by both positive and negative damage multipliers. starting, blue, white, glow, cross, You can now break obstacles by walking over them, Holes in the ground can be filled by crushing adjacent rocks, similar to how this can be done with bombs, * item room, treasure room, item room pool, cheetos, cheese, grey, gray, orange, jar, Enemies and pickups (keys, bombs etc.) Transformations 's unique poops, Corn poop - Spawns a blue fly every 2 seconds, Flaming poop - Leaves behind fire that damages enemies, Black poop - Creates slowing black creep. Based on the Steam Workshop mod created by Amethyst, UNLOCK: Unlock this item by using 5 Gulp! It returns after a room has been cleared, UNLOCK: Unlock this item by beating Greed Mode with Eden, Item Pool: Item Room, Secret Room, Greed Mode Shop, *, red, yellow, green, white, square, rectangle, When used, the D8 rerolls all of your stats, Will only effect your damage, tears, range and speed stats, Each stat is given a multiplier that applies after all other adjustments, UNLOCK: Unlock this item by beating Challenge #28 (Pride Day), * dice, pip, die, black, grey, gray, pyramid, triangle, Purity will boost one of Isaac's stats depending on the colour of the aura around him, When you take damage, the aura will be removed and replaced with another random one when you enter the next room, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Maggy, Item Pool: Item Room, Angel Room, Greed Mode Item Room, Greed Mode Angel Room, Adds a chance for a black ring to spawn around killed enemies, dealing damage to others that touch it, The ring damage scales with your tear damage, The change for a ring to spawn scales with your lucky stat, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Eve, Item Pool: Devil Room, Curse Room, Greed Mode Devil Room, *, grey, gray, silver, metal grabber, hand, robot, When Isaac has no red hearts, this item gives Isaac the ability to fly. This includes all sources of damage, including environmental damage to enemies, Killing an enemy while berserk will increase the duration of the effect by 1 second, You don't die while in Berserk mode, but taking lethal damage will kill you after the effect wears off, The bone sword from this item is similar to Donkey Jawbone from Antibirth, Tainted Samson starts with a passive version of this item, UNLOCK: Unlock this item by defeating Delirium as Tainted Samson, Recharge time: Enemy damage taken = charge, When used, Isaac turns into a ghost for 1 second and his speed goes up to maximum (2.0). The effect is weaker than normal runes. UNLOCK: Unlock this card by beating Challenge #12 (When Life Gives You Lemons), When used, will open all doors in the current room, similar to a one-time use of Dad's Key, UNLOCK: Unlock this card by beating Challenge #22 (Speed), When used this card will activate a use of your spacebar item for free, When used, this rune will destroy all breakable objects in the current room, such as poop, rocks, secret room entrances, UNLOCK: Unlock this card by beating Challenge #1 (Pitch Black), When used this rune will double all pickups on the floor in the room, Creates copies of pickups in the Shop which can be taken for free, even if you haven't purchased them yet, Can be used to double the number of item chests in the first room of the final Chest / Dark Room floors, Cloned chests have the same types of items as the first one, Cannot be used to clone trinkets or other Jera runes, UNLOCK: Unlock this card by beating Challenge #2 (High Brow), UNLOCK: Unlock this card by beating Challenge #3 (Head Trauma), Removes the curse which is in effect on the current floor (except Curse of the Labyrinth), Can also cure the effect of the Amnesia pill, UNLOCK: Unlock this card by beating Challenge #4 (Darkness Falls), When used, reveals the entire map including all the secret room locations and other icon rooms, UNLOCK: Unlock this card by beating Challenge #5 (The Tank), Rerolls all pedestal items in the current room (One time use of the D6), UNLOCK: Unlock this card by beating Challenge #6 (Solar System), Summons 3 blue friendly spiders and 3 blue flies, UNLOCK: Unlock this card by beating Challenge #20 (Purist), When used, gives you an invincibility effect which lasts for 20 seconds, UNLOCK: Unlock this card by beating Challenge #8 (Cat Got Your Tongue), When used, gives a random Mystic rune effect, Possible effects include: Algiz, Ansuz, Berkano, Dagaz, Ehwaz, Hagalaz, Jera, Perthro, Also has a 25% chance to spawn another Blank Rune upon use, UNLOCK: Unlock this card by beating Challenge #30 (Guardian), When used, this rune deals 40 damage to all enemies in the room and consumes all pedestal items in the room, giving you a random stat increase for each item consumed, Also consumes all pickups in the room and turns them into blue flies and spiders, UNLOCK: Unlock this item by beating Greedier mode as Apollyon. Releasing Dark Esau will cause him to charge directly at Jacob and deal damage to anything in his path. Both charge at the same time and using Anima Sola chains both in the same spot, Significantly increases damage by +21.6, however the damage boost wears off slowly over time at a rate of roughly -0.04 per second, Every enemy you kill adds +0.02 Damage to the timed effect of Red Stew, UNLOCK: Unlock this item by defeating Satan as Jacob & Esau, When used, removes all your passive items and teleports you to Isaac's Bedroom, For every passive item removed, you are given a choice of 3 random pedestal items from any item pool. Curses - Turns Isaac invincible for a few seconds (similar to Unicorn Stump). ?, Satan and The Lamb as Tainted Apollyon, Gives you a red attack fly, that will charge at enemies in the same direction you are shooting, Deals damage equal to your current tear damage, Stops charging once it hits an enemy and returns to Isaac's side, UNLOCK: Unlock this trinket by defeating Mother as Tainted Apollyon, Gives a 33% chance to spawn an extra blind pedestal item in all future item rooms. Tear Appearance Modes Effects Counts as 1 of 3 spider items needed towards the Spider Baby transformation. - Speeds up all enemies for the rest of the room. Using this card will also open a pathway of red rooms back to the regular floor, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Jacob, "May the darkness swallow all around you", When used, grants +1.5 Damage Up, turns your hearts to Bone hearts and the Spirit of the Night effect (Spectral tears and the ability to fly) for the current floor, Also gives the Curse of Darkness effect that can't be removed for the current floor, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Lazarus, Creates a trapdoor to a guaranteed crawl space, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Eden, When used, this copies the effect of the card, pill, rune, soul stone or active item you used most recently, UNLOCK: Unlock this card by defeating Mega Satan as Tainted Eden, Turns all pedestal items in the current room into rotating items, which cycle between the old item and a random new item every second, This allows you to effectively reroll items like with The D6, but choose the old item as well if you want, Tainted Isaac has this effect passively for all items, If you use more than one in the same room, each pedestal item will cycle through +1 random item, Items are chosen from the item pool related to the current item, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Isaac, When used, all enemies in the current room drop half a red heart that will disappear after 2 seconds if not picked up, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Magdalene, When used, this Soul Stone creates Red rooms for every possible exit in the current room, Red outlines of doors appear where this Soul Stone will create exits for, See the Red Key item description for more information about these Red rooms behave, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Cain, Activates the Dark Arts item effect, which turns Isaac into a ghost for a few seconds. If picked up by Cain, it shoots blood tears and the damage becomes increased to 5 (instead of the usual 3.5), UNLOCK: Unlock this item by beating the Dark Room with Cain, * golden chest pool, gold chest pool, item room, treasure room, item room pool, follower, everyone knows it's abel, brown, grey, gray, dead, head, grey, green cain and abel cain & abel, UNLOCK: Unlock this item by beating Challenge #14 (It's in the Cards), * item room, treasure room, item room pool, bloody, silver, grey, gray, sharp, Item Pool: Item Room, Secret Room, Bomb Beggar, * secret room pool, item room, treasure room, item room pool, smile, face, grinning, doitfgt, REPENTANCE - The list of possible tear effects was updated in Repentance, to include all missing and new ones, * item room, treasure room, item room pool, pink note, money, cash, three dollar bill, rocks, pots, stone blocks), All rocks spawn 0-2 blue spiders when destroyed, UNLOCK: Unlock this item by defeating Delirium as Tainted Keeper, When used, spawns a random shop item or consumable, however you have to pay the relevant cost to pick it up, Can include anything that would appear in the shop, UNLOCK: Unlock this item by defeating The Beast as Keeper, Item Pool: Shop, Secret Room, Wooden Chest, With every bar of charge this item has, a different consumable is shown inside the Jar. The number of burst tears is random between 6-11 and they have equal chance. This bug was popularized by a YouTuber called Bisnap and named Brimsnap by a streamer called "CobaltStreak". No longer has an "on hit" effect, UNLOCK: Unlock this item by donating 999 pennies to the Shop, * shop room pool, shop item pool, stopwatch, blue, pocket, clock, Tears now revolve around Isaac's Body at a fixed distance until they hit the ground, Aiming in the opposite direction is often better due to how the tears circle around Isaac, Causes a lot of great synergies with items such as Lump of Coal, Brimstone, Rubber Cement, Technology and most of the worm trinkets, REPENTANCE - Tiny Planet's orbit now more tightly follows Isaac. The mirrored floor rooms have respawned enemies, and allows you to optionally fight the Boss a second time for an extra item, When combined with Knife Piece 2, can be used to stab the fleshy door in the Mausoleum II, which then leads to the Corpse floor and the Mother boss, Combine with Knife Piece 1 to create a Knife which can be fired across the room, dealing 25 damage to any enemies it comes into contact with, In the Mines/Ashpit II, there's a room with a minecart and a broken track. It will also sometimes randomly drop bombs. . The 2 permanent stat increases depend on the item taken: A Snack = +0.2 shot speed, +1 luck. Gives a small chance when entering a room for enemies to be petrified for 4 seconds. ipecac isaac seedhegelian theory of social change. Now grants a half black heart upon use instead of a full soul heart. ?s only friend, blue bozzy, An iron ball and chain attached to Isaac, similar to Guppy's Hairball that you can fling around to deal 5 damage per tick, The ball will block enemy shots and can also destroy environmental objects such as rocks, mushrooms and skulls, Does not decrease your movement speed stat at all however the ball has to be dragged around causing Isaac to slow down slightly when the chain is fully extended, UNLOCK: Unlock this item by beating Boss Rush with Samson, * secret room pool, item room, treasure room, item room pool, grey, gray, shackle, A familiar that will follow Isaac and copy the effect of one of your other familiars, If you don't have any other familiars, he will just shoot normal tears, REPENTANCE - Removed the double damage multiplier on Mongo Baby's attacks, * item room, treasure room, item room pool, pink, blue, grey, gray, An active item that fires 8 of Isaac's tears in a circle around him, Tears spawned from this item keep most effect that Isaac currently has applied to his tears, and deal an additional +5 flat damage, UNLOCK: Unlock this item by beating the Isaac boss with Isaac, * item room, treasure room, item room pool, glass, blue, water, isaacs tears, Upon use, teleports you to one of the following rooms at random: Item room, Secret room, Super secret room, the I AM ERROR room or the Black Market (very low chance), There are no I AM ERROR rooms on the final floors, preventing looping with this item, UNLOCK: Unlock this item by beating Boss Rush with Eden, * item room, treasure room, item room pool, pink, purple, red, broken, When used will cut your head from your body. 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