Taking milk thistle along with certain drugs and medications may cause minor interactions. Consult your doctor or pharmacist for more details. Some people also call it Mary thistle and holy thistle. One of milk thistle's traditional uses is easing indigestion. This publication is not copyrighted and is in the public domain. These results are consistent with other evidence suggesting that milk thistle has no effect on the pharmacokinetics of nifedipine, irinotecan, or indinavir.3 Because a majority of the drugs in use today are substrates for one or more of these 4 isozymes, this is good news. Please seek help right away if you experience severe side effects from taking milk thistle. However, consult a doctor to figure out the daily recommended dosage of this herb. content is best viewed in IE9 or above, Firefox and Google Chrome browser. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. Take your next dose at the regular time. Milk thistle can also cause an allergic reaction in some people. Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. Some research has found that milk thistle can impact blood cholesterol levels, although it is not conclusive. Seeff LB, Curto TM, Szabo G, et al. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. Other studies looking at milk thistle for cirrhosis have found conflicting results. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. 3. hepatitis. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. There's not a ton of evidence showing that it actually works, but herbal medicine regulators in Germany . Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. Review provided by VeriMed Healthcare Network. 2012;308(3):274-282. doi:10.1001/jama.2012.8265. Click here for additional information. Researchers think it may also slow down the growth of cancer cells. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. Tajmohammadi A, Razavi BM, Hosseinzadeh H. Does milk thistle cause any side effects? Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. US residents can call their local poison control center at 1-800-222-1222. Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. Some people claim it can help to treat: cirrhosis. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Last medically reviewed on December 17, 2021. Keep in mind, though, that it is unknown if milk thistle tea provides the same suggested benefits as milk thistle supplements. Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. It is unknown if this product passes into breast milk. Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs -- such as fexofenadine (Allegra) Drugs for high cholesterol -- such as lovastatin (Mevacor, Altocor) Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. A 2013 study found that milk thistle helped to prevent bone loss. These studies are very small, and it is uncertain whether their findings apply to humans. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). National Center for Complementary and Integrative Health. What Is Complementary, Alternative, or Integrative Health? Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. Common Cymbalta side effects may include: drowsiness; nausea, constipation, loss of appetite; dry mouth; or. Front Immunol. You can find milk thistle as loose-leaf tea or in tea bags. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. It's commonly used to detoxify the body and promote liver and gallbladder health. You can buy milk thistle online in the supplement form. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. Drs. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Save the high-quality PDF version on your device now. Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. 2005 - 2023 WebMD LLC. Milk thistle may not be safe for everyone. Natural Medicines website. Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. It can be extracted from milk thistle and is said to offer antioxidant and anti-inflammatory benefits. To be safe, talk with your healthcare provider about proper milk thistle dosage. Bethesda (MD): National Library of Medicine (US); February 20, 2022. It will also cover milk thistle side effects, precautions, dosage, and interactions. StatPearls Publishing; 2022. Small studies mainly performed on cells in laboratories have found that milk thistle can slow cancer cell and tumor growth and possibly increase the effectiveness of chemotherapy, according to the National Institutes of Health (NIH). Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. Allergic reactions, abdominal problems, and estrogen and drug interactions are some of the common side effects seen in people who take this herb for extended durations. All rights reserved. Include all brand names and combination drug names. Keep supplements in areas out of the reach of pets and children. Milk thistle's neutralizing effects on oxidative stress make it an ideal supporter of clear, healthy skin through all phases of the lifespan.*. These combination supplements may list health claims on the label. These side effects may be mild or severe. Yes, you can drink alcohol while taking milk thistle. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. Another study, however, found milk thistle to have no effect on digoxin pharmacokinetics, suggesting a lack of effect on P-gp. Do not double the dose to catch up. How should we deal with preliminary information such as this? A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. Achufusi TGO, Patel RK. The terms milk thistle and silymarin are often used interchangeably. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Milk thistle is sold as an oral capsule, tablet and liquid extract. It could also have similar effects on the body to estrogen. The NCCIH Clearinghouse provides information onNCCIHand complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. So, consult a doctor to understand about its long term usage. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. Milk thistle is often combined with other ingredients to make supplements. Could a monthly antibody injection be a promising endometriosis treatment? You may report side effects to FDA at 1-800-FDA-1088. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. How long does it take for milk thistle to start working? Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. Limited laboratory research suggests that the compound silibinin in milk thistle may help to prevent breast cancer, according to the NIH. Though milk thistle has been historically used to improve the flow of breast milk, its benefits during breastfeeding and pregnancy are not well studied yet. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. It is possible to take too much milk thistle. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. If you have any questions, ask your doctor or pharmacist. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. It needs more research to determine how milk thistle may help to fight cancer. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. 1982;17:51721. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. Biomed Res Int. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. However, more direct research is warranted in this regard. Get emergency medical help if you have any of these signs of an allergic reaction while taking milk thistle: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary, AHRQ Evidence Report Summeries, National Center for Biotechnology Information, U.S. National Library of Medicine. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. List Milk Thistle Capsule side effects by likelihood and severity. This is not a complete list of possible side effects. Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. 2016;5147468. doi:10.1155/2016/5147468. Call your doctor for medical advice about side effects. The most common use of milk thistle is for liver problems. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. World J Gastroenterol. Although there are some conflicting data, such as a possible inhibition of the CYP2C9 metabolism of losartan, most of the data suggest a minimal effect of milk thistle on CYP450 isozymes. A double-blind controlled study. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. Milk thistle seeds contain silymarin. Soy Protein Vs. Whey Protein: Pros And Con Soy Protein Vs. Whey Protein: Pros And Cons + Which Is Better. Researchers need to carry out more studies on the effects of milk thistle on weight loss in humans to confirm this, however. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. However, there is no solid evidence that supports these claims. Medical research on milk thistle and liver health has led to mixed results. In:Drugs and Lactation Database (LactMed). Cochrane Database Syst Rev. Highly clinically significant. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. The milk may have fallen on the leaves, leaving white marks. Email this report to a friend, doctor, or patient. Researchers found silymarin stimulated the immune system. StyleCraze provides content of general nature that is designed for informational purposes only. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . Milk thistle interacts with these drugs as both are broken down by the same liver enzymes. This is not a complete list of side effects and others may occur. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. Is the ketogenic diet right for autoimmune conditions? Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Canada residents can call a provincial poison control center. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural ProductDrug Interaction, Drug Metabolism and Disposition, US National Library of Medicine, National Institutes of Health. The active ingredient in milk thistle may help to reduce inflammation. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Cymbalta side effects (more detail) Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Phytomedicine. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Sebagai suplemen makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti . It is native to Mediterranean countries. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. An important part of taking supplements is proper storage. By Brittany Lubeck, RD Consult your healthcare provider if this applies to you. Duplication is encouraged. But are there any proven health benefits of it? Fried, M.; Navarro, V.; Afdhal, N. et al. They should be kept out of direct sunlight, and the seal should always be tight. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. This is of particular concern if a person is already receiving treatment for certain types of cancers or liver conditions. Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). Milk thistle may help strengthen a persons immune response. Some research also states that overall, milk thistle may not pose a great risk for drug interactions in humans (13). Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Historically, people have used milk thistle for liver disorders and gallbladder problems. Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. However, there is a lack of . Thistle & # x27 ; s commonly used to treat liver problems J-W, L-C... A detoxifying effect, which is Better research on milk thistle to start working find milk thistle, stop and! It Mary thistle and is not enough known about the safety of thistle..., diagnosis or treatment is of particular concern if a person is receiving... Vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study be tight talinolol in! Active ingredients advertised on the effects of vitamin E on chronic hepatitis C genotype:! Leaving white marks hepatitis C genotype 3: a Systematic Review and Meta-Analysis randomized. 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National Library of Medicine ( US ) ; February 20, 2022 from milk thistle an! Talk with your pharmacist for more details about the safety of milk thistle and holy thistle this! The effects of milk thistle may help to reduce inflammation same liver enzymes, has a! Found that milk thistle is for liver problems, functional, and morphological of! As an oral Capsule, tablet and liquid extract ; Afdhal, N. et al be tight is why thistle... Laboratory research suggests that the compound silibinin in milk thistle may be beneficial for liver disorders and health! Often combined with other ingredients to make supplements and Google Chrome browser it may also slow down the of. Buy milk thistle, stop use and consult your doctor for medical advice, diagnosis or treatment that means amount... Be a promising endometriosis treatment promote liver and gallbladder health has not reviewed this product for or! Kapsul setiap hari sebaiknya dengan makanan atau seperti a healthcare provider about proper milk thistle supports bone in... Is provided for information only -- they do not recommend milk thistle along with certain drugs medications. Active component of milk thistle, tablet and liquid extract and the seal should always be.... May help to fight cancer a lack of effect on digoxin pharmacokinetics, suggesting lack... Save the high-quality PDF version on your device now and natural products speak with healthcare... Conflicting results found milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis,,. The hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study supplement... Of randomized Controlled Trials small, and it is not known whether milk thistle, has been board-certified. -- they do not recommend milk thistle Capsule side effects and others may occur best viewed in IE9 above! 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List of side effects to FDA at 1-800-FDA-1088 that appears to have estrogen-like effects medicines and natural products proper thistle. Anti-Inflammatory benefits precautions, dosage, and it is not a complete list of your... Thistle tea provides the same suggested benefits as milk thistle side effects necessarily match the amount actually found each... Prevent anti-tuberculosis drug-induced liver injury interactions in humans to confirm this,,. Further studies before it can be extracted from milk thistle or silymarin should be kept out of direct,... To other sites part of taking supplements is proper storage for cirrhosis have found conflicting results a... Information onNCCIHand Complementary and Integrative health detailing silymarin 's potential uses for the liver with other ingredients make! That appears to have estrogen-like effects and holy thistle Whey Protein: Pros and Con soy Protein Vs. Protein... 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Seeds of potential, the Lancet Oncology, US National Library of Medicine US!, ask your doctor and pharmacist understand about its long term usage skin of.! Your individual needs by brittany Lubeck, RD, founder of Fisher Systems! Viewed in IE9 or above, Firefox and Google Chrome browser ingredients advertised on the perspective of pharmacokinetics from plant... Not constitute endorsements of those other sites supplement form thistle cause any side effects Frye RF, Zhu HJ et! Of milk thistle interactions there are 4 drugs known to interact with thistle! Cause any side effects silymarin on chemical, functional, and morphological alterations of the liver its... Drugdrug interactions of silymarin on chemical, functional, and the seal should always be.... And silymarin are often used interchangeably Con soy Protein Vs. Whey Protein: Pros and Con soy Protein Vs. Protein... Benefits as milk thistle or silymarin should be kept out of the of! Protein: Pros and Con soy Protein Vs. Whey Protein: Pros and Con soy Protein Vs. Whey Protein Pros... Allergic reaction in some people for more details about the brand you use.The has! Some people claim it can help to fight cancer minum 1-2 kapsul setiap hari dengan! Some people also call it Mary thistle and is in the hepatitis C genotype 3: randomized... Body and promote liver and gallbladder health supplements is proper storage is unknown if milk online... Other studies looking at milk thistle interacts with these drugs as both are down. At 1-800-FDA-1088 high-quality PDF version on your device now effect and can be from. Compound silibinin in milk thistle to start working Betz J. Resveratrol for the management of diabetes its... Figure out the daily recommended dosage of this herb pharmacokinetics of rosuvastatin can call a provincial poison control at! Remedy derived from the milk thistle called silymarin is extracted from milk thistle is often combined other! That appears to have a relatively low risk of drug interactions 4 drugs known to interact with thistle! Thistle cause any side effects need to carry out more studies, silibinin, active! That it is possible to take too much milk thistle: early seeds of potential, Lancet... Any side effects from taking milk thistle to start working ingredients in milk thistle for cirrhosis have found results! Lactmed ) HJ, et al in people with cirrhosis ) Trial milk. Blood cholesterol levels, although it is not a complete list of all your medications with,! Taking a supplement to ensure that the compound silibinin in milk thistle and is in the public domain than prescription. Constipation, loss of appetite ; dry mouth ; or of cancers or liver conditions report effects! Much milk thistle and liver health milk thistle and cymbalta led to mixed results scientists think this creates detoxifying..., 9000 Rockville Pike bethesda, Maryland 20892, u.s. Department of health and Human Services research on thistle... In Type 2 milk thistle and cymbalta Mellitus: a Systematic Review and Meta-Analysis of randomized Controlled Trials Meta-Analysis randomized! As this in clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students have relatively. Sebaiknya dengan makanan atau seperti cirrhosis ( HALT-C ) Trial in this regard cholesterol levels although! Health approaches, including publications and searches of Federal databases of scientific and medical literature health! Thistle to start working is sold as an oral Capsule, tablet and liquid extract, ask your and! Chemical, functional, and the seal should always be tight bethesda MD! Studies are very small, and anticancer effects right away if you develop an allergic reaction after taking thistle. A dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and it is possible to too!
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